DMT, Ayahuasca, and MAOIs

Dimethyltryptamine, or DMT, is perhaps the most potent psychedelic known to man. Potency aside (experiencing DMT requires a mere 50 mg), DMT commands significant respect due to the intense psychoactive odyssey it imparts upon those who venture forward. In modern times those attempting to breakthrough often consume DMT via inhalation (smoking). If attempting other routes, a DMT user may become disappointed. That is, unless their preparation contains a monoamine oxidase inhibitor (MAOI). The goal of this article will be to provide some clarification as to why oral DMT use necessitates the addition of an MAOI.


DMT provides an introspective journey as its users “breakthrough to the other side.” Molecularly, DMT is a tryptamine that has been dimethylated. Dimethylation occurs following the addition of two carbon atom. Tryptamine is structurally similar to the well-known neurotransmitter serotonin, which speaks to the etiology of tryptamine-containing compounds’ associated psychoactivity. Other notable tryptamines are AMT, 5-MeO-DiPT, and 4-HO-DMT.


The word tryptamine is strongly associated with hallucinogens. Alkaloids of psilocybin-containing mushrooms are perhaps

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